Lifetime prevalence of mood and anxiety disorders in fragile X premutation carriers
Identifieur interne : 001A22 ( Main/Exploration ); précédent : 001A21; suivant : 001A23Lifetime prevalence of mood and anxiety disorders in fragile X premutation carriers
Auteurs : James A. Bourgeois [États-Unis] ; Andreea L. Seritan [États-Unis] ; E. Melina Casillas ; David Hessl [États-Unis] ; Andrea Schneider [États-Unis] ; Ying Yang ; Inderjeet Kaur ; Jennifer B. Cogswell ; Danh V. Nguyen ; Randi J. HagermanSource :
- The Journal of clinical psychiatry [ 0160-6689 ] ; 2010.
Abstract
The authors studied the lifetime prevalence of DSM-IV-TR psychiatric disorders in a population of adults with the fragile X premutation.
Structured Clinical Interview for DSM-IV (SCID) were conducted on 85 individuals with the fragile X premutation, 47 with the fragile X-associated tremor/ataxia syndrome (FXTAS; 33 male, 14 female, mean age 66) and 38 without FXTAS (16 male, 22 female, mean age 52). Lifetime prevalence for mood and anxiety disorders among carriers with and without FXTAS was compared to available age-specific population estimates from the National Comorbidity Survey Replication (NCS-R).
Among subjects with FXTAS, 30 cases (65%) met lifetime DSM-IV-TR criteria for mood disorder; 24 cases (52%) met lifetime DSM-IV-TR criteria for anxiety disorder. Among the non-FXTAS subjects, there were 15 cases (42%) of lifetime mood disorder and 18 cases (47%) of lifetime anxiety disorder. When compared to age-specific NCS-R data, the lifetime prevalence of any mood disorder, major depressive disorder, any anxiety disorder, panic disorder, specific phobia, and PTSD were significantly higher in subjects with FXTAS. The lifetime rates of social phobia in individuals with the premutation without FXTAS were significantly higher than NCS-R data.
This sample of carriers of the fragile X premutation had a notably high lifetime risk of mood and anxiety disorders. Mood and anxiety disorders may be part of the clinical phenotype of the fragile X premutation conditions, especially in carriers with FXTAS. Clinicians encountering these patients are advised to consider FXTAS as a neuropsychiatric syndrome as well as a neurological disorder.
Url:
DOI: 10.4088/JCP.09m05407blu
PubMed: 20816038
PubMed Central: 4038118
Affiliations:
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Bourgeois</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento</wicri:cityArea></affiliation></author><author><name sortKey="Seritan, Andreea L" sort="Seritan, Andreea L" uniqKey="Seritan A" first="Andreea L." last="Seritan">Andreea L. 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Institute, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation><affiliation><nlm:aff id="A4">Department of Pediatrics, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Hessl, David" sort="Hessl, David" uniqKey="Hessl D" first="David" last="Hessl">David Hessl</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento</wicri:cityArea></affiliation><affiliation><nlm:aff id="A2">M.I.N.D. Institute, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Schneider, Andrea" sort="Schneider, Andrea" uniqKey="Schneider A" first="Andrea" last="Schneider">Andrea Schneider</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento</wicri:cityArea></affiliation><affiliation><nlm:aff id="A2">M.I.N.D. Institute, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Ying" sort="Yang, Ying" uniqKey="Yang Y" first="Ying" last="Yang">Ying Yang</name><affiliation><nlm:aff id="A3">Department of Public Health Sciences, University of California, Davis, Davis CA</nlm:aff><wicri:noCountry code="subfield">Davis CA</wicri:noCountry></affiliation></author><author><name sortKey="Kaur, Inderjeet" sort="Kaur, Inderjeet" uniqKey="Kaur I" first="Inderjeet" last="Kaur">Inderjeet Kaur</name><affiliation><nlm:aff id="A2">M.I.N.D. Institute, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Cogswell, Jennifer B" sort="Cogswell, Jennifer B" uniqKey="Cogswell J" first="Jennifer B." last="Cogswell">Jennifer B. Cogswell</name><affiliation><nlm:aff id="A2">M.I.N.D. Institute, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation><affiliation><nlm:aff id="A4">Department of Pediatrics, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation></author><author><name sortKey="Nguyen, Danh V" sort="Nguyen, Danh V" uniqKey="Nguyen D" first="Danh V." last="Nguyen">Danh V. Nguyen</name><affiliation><nlm:aff id="A3">Department of Public Health Sciences, University of California, Davis, Davis CA</nlm:aff><wicri:noCountry code="subfield">Davis CA</wicri:noCountry></affiliation></author><author><name sortKey="Hagerman, Randi J" sort="Hagerman, Randi J" uniqKey="Hagerman R" first="Randi J." last="Hagerman">Randi J. Hagerman</name><affiliation><nlm:aff id="A2">M.I.N.D. Institute, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation><affiliation><nlm:aff id="A4">Department of Pediatrics, University of California, Davis Medical Center</nlm:aff><wicri:noCountry code="subfield">Davis Medical Center</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of clinical psychiatry</title><idno type="ISSN">0160-6689</idno><idno type="eISSN">1555-2101</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">The authors studied the lifetime prevalence of DSM-IV-TR psychiatric disorders in a population of adults with the fragile X premutation.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Structured Clinical Interview for DSM-IV (SCID) were conducted on 85 individuals with the fragile X premutation, 47 with the fragile X-associated tremor/ataxia syndrome (FXTAS; 33 male, 14 female, mean age 66) and 38 without FXTAS (16 male, 22 female, mean age 52). Lifetime prevalence for mood and anxiety disorders among carriers with and without FXTAS was compared to available age-specific population estimates from the National Comorbidity Survey Replication (NCS-R).</p></sec><sec id="S3"><title>Results</title><p id="P3">Among subjects with FXTAS, 30 cases (65%) met lifetime DSM-IV-TR criteria for mood disorder; 24 cases (52%) met lifetime DSM-IV-TR criteria for anxiety disorder. Among the non-FXTAS subjects, there were 15 cases (42%) of lifetime mood disorder and 18 cases (47%) of lifetime anxiety disorder. When compared to age-specific NCS-R data, the lifetime prevalence of any mood disorder, major depressive disorder, any anxiety disorder, panic disorder, specific phobia, and PTSD were significantly higher in subjects with FXTAS. The lifetime rates of social phobia in individuals with the premutation without FXTAS were significantly higher than NCS-R data.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This sample of carriers of the fragile X premutation had a notably high lifetime risk of mood and anxiety disorders. Mood and anxiety disorders may be part of the clinical phenotype of the fragile X premutation conditions, especially in carriers with FXTAS. Clinicians encountering these patients are advised to consider FXTAS as a neuropsychiatric syndrome as well as a neurological disorder.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Casillas, E Melina" sort="Casillas, E Melina" uniqKey="Casillas E" first="E. Melina" last="Casillas">E. Melina Casillas</name><name sortKey="Cogswell, Jennifer B" sort="Cogswell, Jennifer B" uniqKey="Cogswell J" first="Jennifer B." last="Cogswell">Jennifer B. Cogswell</name><name sortKey="Hagerman, Randi J" sort="Hagerman, Randi J" uniqKey="Hagerman R" first="Randi J." last="Hagerman">Randi J. Hagerman</name><name sortKey="Kaur, Inderjeet" sort="Kaur, Inderjeet" uniqKey="Kaur I" first="Inderjeet" last="Kaur">Inderjeet Kaur</name><name sortKey="Nguyen, Danh V" sort="Nguyen, Danh V" uniqKey="Nguyen D" first="Danh V." last="Nguyen">Danh V. Nguyen</name><name sortKey="Yang, Ying" sort="Yang, Ying" uniqKey="Yang Y" first="Ying" last="Yang">Ying Yang</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Bourgeois, James A" sort="Bourgeois, James A" uniqKey="Bourgeois J" first="James A." last="Bourgeois">James A. Bourgeois</name></region><name sortKey="Hessl, David" sort="Hessl, David" uniqKey="Hessl D" first="David" last="Hessl">David Hessl</name><name sortKey="Schneider, Andrea" sort="Schneider, Andrea" uniqKey="Schneider A" first="Andrea" last="Schneider">Andrea Schneider</name><name sortKey="Seritan, Andreea L" sort="Seritan, Andreea L" uniqKey="Seritan A" first="Andreea L." last="Seritan">Andreea L. Seritan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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